Publications scientifiques

  1. Li J, Zhu X, Yu K, Jiang H, Zhang Y, Wang B, Liu X, Deng S, Hu J, Deng Q, Sun H, Guo H, Zhang X, Chen W, Yuan J, He M, Bai Y, Han X, Lin B, Liu C, Guo Y, Zhang B, Zhang Z, Hu FB, Gao W, Li L, Lathrop M, Laprise C, Liang L, Wu T. Exposure to Polycyclic Aromatic Hydrocarbons and Accelerated DNA Methylation Aging. Environ Health Perspect. 2018 Juin 14;126(6) :067005
  2. Forbes JD, Azad MB, Vehling L, Tun HM, Konya TB, Guttman DS, Field CJ, Lefebvre D, Sears MR, Becker AB, Mandhane PJ, Turvey SE, Moraes TJ, Subbarao P, Scott JA, Kozyrskyj AL; CHILD Study Investigators. Association of Exposure to Formula in the Hospital and Subsequent Infant Feeding Practices With Gut Microbiota and Risk of Overweight in the First Year of Life. JAMA Pediatr. 2018 Juin 4; epub ahead of print
  3. Kamal M, Tamana SK, Smithson L, Ding L, Lau A, Chikuma J, Mariasine J, Lefebvre DL, Subbarao P, Becker AT, Turvey SE, Sears MR, CHILD Study Investigators, Pei J, Mandhane PJ. Phenotypes of sleep-disordered breathing symptoms to two years of age based on age of onset and duration of symptoms. Sleep Med. 2018 Mai 3;48:93-100
  4. Miliku K, Robertson B, Sharma AK, Subbarao P, Becker AB, Mandhane PJ, Turvey SE, Lefebvre DL, Sears MR; CHILD Study Investigators, Bode L, Azad M. Human milk oligosaccharide profiles and food sensitization among infants in the CHILD Study. Allergy. 2018 Mai 18; epub ahead of print
  5. Sugier PE, Brossard M, Sarnowski C, Vaysse A, Morin A, Pain L, Margaritte-Jeannin P, Dizier MH, Cookson WOCM, Lathrop M, Moffat MF, Laprise C, Demenais F, Bouzignon E. A novel role for ciliary function in atopy: ADGRV1 and DNAH5 J Allergy Clin Immunol. 2018 Mai;141(5):1659-1667.e11
  6. Xu CJ, Söderhäll C, Bustamante M, et al. DNA methylation in childhood. DNA methylation in childhood asthma: an epigenome-wide meta-analysis. Lancet Resp Med. 2018 Mai;6(5):379-388
  7. Smithson L, Baird T, Tamana SK, Lau A, Mariasine J, Chikuma J, Lefebvre DL, Subbarao P, Becker AT, Turvey SE, Sears MR, CHILD Study Investigators, Beal DS, Pei J, Mandhane PJ. Shorter sleep duration is associated with reduced cognitive development at two years age. Sleep Med. 2018 Avril;48:131-139
  8. Tun HM, Bridgman SL, Chari R, Field CJ, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj AL; CHILD Study Investigators. Roles of Birth Mode and Infant Gut Microbiota in Intergenerational Transmission of Overweight and Obesity From Mother to Offspring. JAMA Pediatr. 2018 Avril 1;172(4):368-377
  9. Margaritte-Jeannin P, Babron MC, Laprise C, Lavielle N, Sarnowski C, Brossard M, Moffat M, Gagné-Ouellet V, Etcheto A, Lathrop M, Just J, Cookson WO, Bouzignon E, Demenais F, Dizier MH. The COL5A3 and MMP9 genes interact in eczema susceptibility. Clin Exp Allergy. 2018 Mar;48(3):297-305
  10. Ho B, Greenlaw K, Tuwaijri AA, Moussette S, Martinez F, Giorgio E, Brusco A, Ferrero G, Linhares N, Valadares E, Svartman M, Kalscheuer V, Criado GR, Laprise C, Greenwood C, Naumova A. X chromosome dosage and presence of SRY shape sex-specific differences in DNA methylation at an autosomal region in human cells. Biology of Sex Differences. 2018 Fev 20;9(1):10
  11. Dharma C, Lefebvre DL, Tran MM, Lou WYW, Subbarao P, Becker AB, Mandhane PJ, Turvey SE, Sears MR; CHILD Study Investigators. Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: Effects on allergic diseases. Clin Exp Allergy. 2018 Jan;48(1):48-59
  12. Demenais F, Margaritte-Jeannin P, Barnes KC & al. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 2018 Jan;50(1):42-53
  13. Mühleisen TW, Reinbold CS, Forstner AJ, et al. Gene set enrichment analysis and expression pattern exploration implicate an involvement of neurodevelopmental processes in bipolar disorder. J Affect Disord. 2017 Nov 14;228:20-25
  14. Tran MM, Lefebvre DL, Dharma C, Dai C, Lou WYW, Subbarao P, Becker AB, Mandhane PJ, Turvey SE, Sears MR; CHILD Study Investigators. Predicting the atopic march: Results from the Canadian Healthy Infant Longitudinal Development Study. J Allergy Clin Immunol. 2017 Nov 1;In press
  15. Klopp A, Vehling L, Becker AB, Subbarao P, Mandhane PJ, Turvey SE, Lefebvre DL, Sears MR; CHILD Study Investigators, Azad MB. Modes of Infant Feeding and the Risk of Childhood Asthma: A prospective Birth Cohort Study. J Pediatr. 2017 Nov; 190: 192-199.e2
  16. Tamana SK, Smithson L, Lau A, Mariasine J, Young R, Chikuma J, Lefebvre DL, Subbarao P, Becker AB, Turvey SE, Sears MR; CHILD Study Investigators, Pei J, Mandhane PJ. Parent-reported symptoms of sleep disordered breathing is associated with increased behavioral problems at 2 years of age: The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study. Sleep. 2017 Nov 1; zsx177
  17. Kang LJ, Koleva PT, Field CJ, Giesbrecht GF, Wine E, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj A;, CHILD Study Investigators. Maternal depressive symptoms linked to reduced fecal Immunoglobulin A concentrations in infants. Brain Behav Immun. 2017 Oct 12;68:123-131
  18. Yasmin F, Tun HM, Konya TB, Guttman DS, Chari RS, Field CJ, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR; CHILD Study Investigators, Scott JA, Dinu I, Kozyrskyj AL. Cesarean section, formula feeding, and infant antibiotic exposure: separate and combined impacts on gut microbial changes in later infancy. Front Pediatr. 2017 Sep 26;5:200
  19. Tran MM, Lefebvre DL, Dai D, Dharma C, Subbarao P, Lou W, Azad MB, Becker AB, Mandhane PJ, Turvey SE, Sears MR; CHILD Study Investigators. Timing of food introduction and development of food sensitization in a prospective birth cohort. Pediatr Allergy Immunol. 2017 Aug 1; 28(5):471-7
  20. Graham C, Chooniedass R, Stefura WP, Becker AB, Sears MR, Turvey SE, Mandhane PJ, Subbarao P, CHILD Study Investigators, HayGlass KT. In vivo immune signatures of healthy human pregnancy: Inherently inflammatory or anti-inflammatory? PLOS one. 2017 Jun 21;12(6):e0177813.
  21. Poon AH, Choy DF, Chouiali F, Ramakrishnan RK, Mahboub B, Audusseau S, Mogas A, Harris JM, Arron JR, Laprise C and Hamid Q. Increased autophagy-related 5 gene expression is associated with collagen expression in the airways of refractory asthmatics. Front Immunol. 2017 Mar 29;8:355.
  22. Moussette S, Al Tuwaijri A, Kohan-Ghadr HR, Elzein S, Farias R, Bérubé J, Ho B, Laprise C, Goodyer CG, Rousseau S, Naumova AK. Role of DNA methylation in expression control of the IKZF3-GSDMA region in human epithelial cells. PLoS One. 2017 Feb 27;12(2):e0172707.
  23. Forstner AJ, Hecker J, Hofmann A, et al. Identification of shared risk loci and pathways for bipolar disorder and schizophrenia. PLoS One. 2017 Feb 6;12(2):e0171595.
  24. Tun HM, Konya T, Takaro TK, Brook JR, Chari R, Field CJ, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj AL; CHILD Study Investigators. Exposure to household furry pets influences the gut microbiota of infant at 3-4 months following various birth scenarios. 2017 Apr 6;5(1):40.
  25. Chen W, Forno E, Wang T, Pino-Yanez M, Liang L, Yan Q, Hu D, Weeks D E., Baccarelli A, Acosta-Perez E, Han Y, Boutaoui N, Laprise C, A. Davies G, M. Hopkin J, F. Moffatt M,  Cookson W, Canino G, Burchard G. E, Celedón JC. An Epigenome-wide Association Study of Total Serum Immunoglobulin E in Hispanic Children. J Allergy Clin Immunol. 2017 Aug;140(2):571-577.
  26. Morin A, Laviolette M, Pastinen T, Boulet LP, Laprise C. Combining -omics data to identify genes associated with allergic rhinitis. Clin Epigenetics. 2017 Jan 18;9:3.
  27. Bolduc FV, Lau A, Rosenfelt CS, Langer S, Wang N, Smithson L, Lefebvre D, Alexander RT, Dickson CT, Li L, Becker AB, Subbarao P, Turvey SE, Pei J, Sears MR, Mandhane PJ; CHILD Study Investigators. Cognitive Enhancement in Infants Associated with Increased Maternal Fruit Intake During Pregnancy: Results from a Birth Cohort Study with Validation in an Animal Model. EBioMedicine. 2016 Jun;8:331-40.
  28. Morin A, Kwan T, Ge B, Letourneau L, Ban M, Tandre K, Caron M, Sandling JK, Carlsson J, Bourque G, Laprise C, Montpetit A, Syvanen AC, Ronnblom L, Sawcer SJ, Lathrop MG, Pastinen T. Immunoseq: the identification of functionally relevant variants through targeted capture and sequencing of active regulatory regions in human immune cells. BMC Med Genomics. 2016 Sep 13;9(1):59.
  29. Bridgman SL, Konya T, Azad MB, Guttman DS, Sears MR, Becker AB, Turvey SE, Mandhane PJ, Subbarao P; CHILD Study Investigators, Scott JA, Field CJ, Kozyrskyj AL. High fecal IgA is associated with reduced Clostridium difficile colonization in infants. Microbes Infect. 2016 Sep;18(9):543-9.
  30. Bridgman SL, Konya T, Azad MB, Sears MR, Becker AB, Turvey SE, Mandhane PJ, Subbarao P; CHILD Study Investigators, Scott JA, Field CJ, Kozyrskyj AL.J Dev Orig Infant gut immunity: a preliminary study of IgA associations with breastfeeding.Health Dis. 2016 Feb;7(1):68-72.
  31. Arrieta MC, Stiemsma LT, Dimitriu PA, Thorson L, Russell S, Yurist-Doutsch S, Kuzeljevic B, Gold MJ, Britton HM, Lefebvre DL, Subbarao P, Mandhane P, Becker A, McNagny KM, Sears MR, Kollmann T; CHILD Study Investigators, Mohn WW, Turvey SE, Finlay BB. Early infancy microbial and metabolic alterations affect risk of childhood asthma.Sci Transl Med. 2015 Sep 30;7(307):307ra152.
  32. Bérubé JC, Gaudreault N, Lavoie-Charland E, Sbarra L, Henry C, Madore AM, Paré PD, van den Berge M, Nickle D, Laviolette M, Laprise C, Boulet LP, Bossé Y. Identification of Susceptibility Genes of Adult Asthma in French Canadian Women. Can Respir J. 2016;2016:3564341.
  33. Sarnowski C, Sugier PE, Granell R, Jarvis D, Dizier MH, Ege M, Imboden M, Laprise C, K. Khusnutdinova E, Freidin B, O.C. Cookson W, Phil D, Moffatt M, Lathrop M, Siroux V, M. Ogorodova L, S. Karuna A, James A, e M. Probst-Hensch N, von Mutius E, Pin I, Kogevinas M, Henderson AJ, Demenais F, Bouzigon E. Identification of a new locus at 16q12 associated with time-to-asthma onset.  J Allergy Clin Immunol. 2016 Oct;138(4):1071-1080.
  34. Madore AM*, T. Vaillancourt V*, Bouzigon E, Sarnowski C, Monier F, Dizier MH, Demenais F and Laprise C. Genes involved in interleukin-1 receptor type II activities are associated with asthma-related phenotypes. Allergy, Asthma & Immunology Research. 2016 Sep;8(5):466-70. *These authors contributed equally to this work
  35. Sarnowski C, Laprise C, Malerba G, Moffatt M, Dizier MH, Morin A, Vincent Q, Rohde K, Esparza-Gordillo J, Margaritte-Jeannin P, Liang L, Lee YA, Bousquet J, Siroux V, Franco Pignatti P, Cookson W, Lathrop M, Pastinen T, Demenais F, Bouzigon E. DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis. J Allergy Clin Immunol. 2016 Sep;138(3):748-53.
  36. Dizier MH, Nadif R, Margaritte-Jeannin P, Barton SJ, Sarnowski C, Gagné-Ouellet V, Brossard M, Lavielle N, Just J, Lathrop M, Holloway JW, Laprise C, Bouzigon E, Demenais F. Interaction between the DNAH9 gene and early smoke exposure in bronchial hyperresponsiveness. Eur Respir J. 2016 Apr;47(4):1072-81.
  37. Al Tuwaijri A, Gagné-Ouellet V, Madore AM, Laprise C, K. Naumova A. Local Genotype Influences DNA Methylation at Two Asthma-Associated Regions 5q31 and 17q21 in a Founder Effect Population. J Med Genet. 2016 Apr;53(4):232-41.
  38. A J Forstner, A Hofmann, & al. Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder. Transl Psychiatry 5: e678.
  39. Lee YA, Marenholz I, Esparza-Gordillo J, Rüschendorf F, Bauerfeind A, Strachan D, Spycher B, Baurecht H, Margaritte-Jeannin P, Sääf A, Kerkhof M, Ege M, Baltic S & al. Meta-analysis identifies 7 susceptibility loci involved in the atopic march. Nat Commun. 2015 Nov 6;6:8804.
  40. Thompson Legault J, Stittmatter L, Tardif J, Sharma R, T. Vaillancourt V, Aubut C, Boucher G, Clish B, Cyr D, Daneault C, Water J. P, The LSFC Consortium, Vachon L, Morin C, Laprise C, Rioux D. J,Mootha K. V, Des Rosiers C. A metabolic signature of mitochondrial dysfunction revealed through a monogenic form of Leigh Syndrome. Cell Rep. 2015 Nov 3;13(5):981-9.
  41. Azad MB, Konya T, Persaud RR, Guttman DS, Chari RS, Field CJ, Sears MR, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL; CHILD Study Investigators. Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study. BJOG. 2016 May;123(6):983-93.
  42. Bchetnia M, Lacroix J, Farez T, Larouche M, Powell J, McCuaig C, Dupéré A, Morin C, Legendre-Guillemin V, Laprise C. Reduction of keratin aggregates in epidermolysis bullosa simplex keratinocytes after pretreatment with trimethylamine N-oxide. Exp Dermatol. 2016 Mar;25(3):229-30.
  43. Gagné-Ouellet V, Guay SP, Boucher-Lafleur AM, Bouchard L, Laprise C. DNA methylation signature of interleukin 1 receptor type II in asthma. Clin Epigenetics. 2015 Aug 5;7(1):80.
  44. Persaud RR, Azad MB, Chari RS, Sears MR, Becker AB, Kozyrskyj AL; the CHILD Study Investigators. Perinatal antibiotic exposure of neonates in Canada and associated risk factors: a population-based study. J Matern Fetal Neonatal Med. 2015 Jul;28(10):1190-5.
  45. Subbarao P, Anand SS, Becker AB, Befus AD, Brauer M, Brook JR, Denburg JA, HayGlass KT, Kobor MS, Kollmann TR, Kozyrskyj AL, Lou WY, Mandhane PJ, Miller GE, Moraes TJ, Pare PD, Scott JA, Takaro TK, Turvey SE, Duncan JM, Lefebvre DL, Sears MR; CHILD Study investigators. The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma. Thorax. 2015 Oct;70(10) :998-1000.
  46. Burelle Y, Bemeur C, Rivard ME, Thompson Legault J, Boucher G; LSFC Consortium, Morin C, Coderre L, Des Rosiers C. Mitochondrial vulnerability and increased susceptibility to nutrient-induced cytotoxicity in fibroblasts from leigh syndrome French canadian patients.PLoS One. 2015 Apr 2;10(3).
  47. Liang L, Willis-Owen SA, Laprise C, Wong KC, Davies GA, Hudson TJ, Binia A, Hopkin JM, Yang IV, Grundberg E, Busche S, Hudson M, Rönnblom L, Pastinen TM, Schwartz DA, Lathrop GM, Moffatt MF, Cookson WO. An epigenome-wide association study of total serum immunoglobulin E concentration. Nature. 2015 Apr 30;520(7549):670-4.
  48. Azad MB, Konya T, Guttman DS, Field CJ, Sears MR, HayGlass KT, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL; CHILD Study Investigators. Infant gut microbiota and food sensitization: associations in the first year of life. Clin Exp Allergy. 2015 Mar;45(3):632-4.
  49. Moraes TJ, Lefebvre DL, Chooniedass R, Becker AB, Brook JR, Denburg J, HayGlass KT, Hegele RG, Kollmann TR, Macri J, Mandhane PJ, Scott JA, Subbarao P, Takaro TK, Turvey SE, Duncan JD, Sears MR, Befus AD; CHILD Study Investigators.The Canadian healthy infant longitudinal development birth cohort study: biological samples and biobanking. Paediatr Perinat Epidemiol. 2015 Jan;29(1):84-92.
  50. Sasarman F, Nishimura T, Antonicka H, Weraarpachai W, Shoubridge EA; LSFC Consortium. Tissue-specific responses to the LRPPRC founder mutation in French Canadian Leigh Syndrome. Hum Mol Genet. 2015 Jan 15;24(2):480-91
  51. Laprise C, Bouzigon E. Understand the allergic diseases biology using human populations by a transdisciplinary approach. Curr Opin Allergy Clin Immunol. 2014 Oct;14(5):379-80.
  52. Konya T, Koster B, Maughan H, Escobar M, Azad MB, Guttman DS, Sears MR, Becker AB, Brook JR, Takaro TK, Kozyrskyj AL, Scott JA; CHILD Study Investigators. Associations between bacterial communities of house dust and infant gut. Environ Res. 2014 May;131:25-30.
  53. Laprise C. The Saguenay-Lac-St-Jean asthma familial collection : the genetics of asthma in a young founder population. Genes and Immunity. 2014 Mar 20  Apr;15(4):247-55.
  54. Dizier MH, Margaritte-Jeannin P, Madore AM, Moffatt M, Brossard M, Lavielle N, Sarnowski C, Just J, Cookson W, Lathrop M, Laprise C, Bouzigon E, Demenais F. The nuclear factor I/A (NFIA) gene is associated with the asthma plus rhinitis phenotype. J Allergy Clin Immunol. 2014 Feb 20.
  55. Bissonnette EY, Madore AM, Chakir J, Laviolette M, Boulet LP, Hamid Q, Bergeron C, Maghni K, Laprise C. Fibrolast growth factor-2 is s sputum rmeodeling biomarker of severe asthma. J Asthma. 2013 Nov 25.
  56. Gauvin H, Moreau C, Lefebvre JF, Laprise C, Vézina H, Labuda D, Roy-Gagnon MH. Genome-wide patterns of identity-by-descent sharing in the French Canadian founder population. Eur J Hum Genet. 2013 Oct 16.
  57. Laprise C, Bouzigon E. The genetics of asthma and allergic diseases: pieces of the puzzle are starting to come together. Curr Opin Allergy Clin Immunol. 2013 Oct;13(5):461-2.
  58. Naumova AK, Al Tuwaijri A, Morin A, Vaillancout VT, Madore AM, Berlivet S, Kohan-Ghadr HR, Moussette S, Laprise C. Sex- and age-dependent DNA methylation at the 17q12-q21 locus associated with childhood asthma. Hum Genet. 2013 Jul;132(7):811-22.
  59. Madore AM, Vaillancourt VT, Asai Y, Alizadehfar R, Ben-Shoshan M, Michel DL, Kozyrskyj AL, Becker A, Chang-Yeung M, Daley D, Clarke AE, Hull P, Sandford AJ and Laprise C. HLA-DQB1 is a genetic determinant for peanut allergy. Eur J Hum Genet. 2013 Oct;21(10):1181-4
  60. Bchetnia M, Farez T, Duval J, Leclerc G, Dupérée A, Powell J, McCuaig C, Morin C, Legendre-Guillemin V, Laprise C. Microarray analysis of epidermolysis bullosa simplex-mottled pigmentation variant. J Dermatol Sci. 2013 Jan;69 (1):80-2.
  61. Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL; CHILD Study Investigators. Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months. CMAJ. 2013 Mar 19;185(5):385-94.
  62. T.Vaillancourt V, Bordeleau M, Laviolette M, Laprise C. From expression pattern to genetic association in asthma related phenotypes. BMC Res Notes. 2012 Nov 13;5:630.
  63. Bouzigon E, Laprise C. Comprehensive integration of genetic and environmental determinants to increase knowledge of the allergic diseases. Curr Opin Allergy Clin Immunol. 2012 Oct;12(5):447-8.
  64. Daley D, Park JE, He JQ, Yan J, Akhabir L, Stefanowicz D, Becker AB, Chan-Yeung M, Bossé Y, Kozyrskyj AL, James AL, Musk AW, Laprise C, Hegele RG, Paré PD, Sandford AJ. Associations and interactions of genetic polymorphisms in innate immunity genes with early viral infections and susceptibility to asthma and asthma-related phenotypes. J Allergy Clin Immunol. 2012 Dec;130(6):1284-93.
  65. Boulay ME, Morin A, Laprise C, Boulet LP. Asthma and rhinitis: what is the relationship? Curr Opin Allergy Clin Immunol. 2012 Oct;12(5):449-54.
  66. Morin A, Brook JR, Duchaine C, Laprise C. Association study of genes associated to asthma in a specific environment, in an asthma familial collection located in a rural area influenced by different industries.Int J Environ Res Public Health. 2012 Aug;9(8):2620-35.
  67. Dizier MH, Margaritte-Jeannin P, Madore AM, Esparza-Gordillo J, Moffatt M, Corda E, Monier F, Guilloud-Bataille M, Franke A, Weidinger S, Annesi-Maesano I, Just J, Pin I, Kauffmann F, Cookson W, Lee YA, Laprise C, Lathrop M, Bouzigon E, Demenais F. The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma. J Allergy Clin Immunol. 2012 Jun;129(6):1547-53.
  68. Poon AH, Gong L, Brasch-Andersen C, Litonjua AA, Raby BA, Hamid Q, Laprise C, Weiss ST, Altman RB, Klein TE. Very important pharmacogene summary for VDR. Pharmacogenet Genomics. 2012 May 14.
  69. Verlaan DJ, Ouimet M, Adoue V, Sirois-Gagnon D, Larivière M, Ge B, Beaulieu P, Dias J, Lam KC, Koka V, Laprise C, Pastinen T, Sinnett D. Promoter polymorphisms in CHI3L1 are associated with asthma. J Allergy Clin Immunol. 2012 Aug;130(2):533-5.
  70. Poon AH, Eidelman DH, Martin JG, Laprise C, Hamid Q. Pathogenesis of severe asthma. Clin Exp Allergy. 2012 May;42(5):625-37.
  71. Poon A, Eidelman D, Laprise C, Hamid Q. ATG5, autophagy and lung function in asthma. Autophagy. 2012 Apr 1;8(4).
  72. Lavoie JP, Lefebvre-Lavoie J, Leclere M, Lavoie-Lamoureux A, Chamberland A, Laprise C, Lussier J. Profiling of differentially expressed genes using suppression subtractive hybridization in an equine model of chronic asthma. PLoS One. 2012;7(1):e29440.
  73. Poon AH, Chouiali F, Tse SM, Litonjua AA, Hussain SN, Baglole CJ, Eidelman DH, Olivenstein R, Martin JG, Weiss ST, Hamid Q, Laprise C. Genetic and histologic evidence for autophagy in asthma pathogenesis. J Allergy Clin Immunol. 2012 Feb;129(2):569-71.
  74. Bchetnia M, Tremblay M-L, Leclerc G, Dupérée A, Powell J, McCuaig C, Morin C, Legendre-Guillemin V, Laprise C. Expression signature of epidermolysis bullosa simplex. Hum Genet. 2011 Aug 30.
  75. Legault J, Perron T, Mshvildadze V, Girard-Lalancette K, Perron S, Laprise C, Sirois P, Pichette A. Antioxidant and Anti-Inflammatory Activities of Quercetin 7-O-β-D-Glucopyranoside from the Leaves of Brasenia schreberi. J Med Food. 2011 Aug 22.
  76. Laprise C, Bouzigon E. To define the biological nature of asthma. Curr Opin Allergy Clin Immunol. 2011 Aug 11.
  77. Poon A, Litonjua AA, Laprise C. Relevance and implication of genetic determinants to asthma pathophysiology. Curr Opin Allergy Clin Immunol. 2011 Aug 4.
  78. Roy-Gagnon MH, Moreau C, Bherer C, St-Onge P, Sinnett D, Laprise C, Vézina H, Labuda D. Genomic and genealogical investigation of the French Canadian founder population structure. Hum Genet. 2011 Jan 15.
  79. Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, von Mutius E, Farrall M, Lathrop M, Cookson WO; GABRIEL Consortium. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med. 2010;363(13):1211-21.
  80. Coutinho M, Encarnação M, Gomes R, Da Silva Santos L, Martins S, Sirois-Gagnon D, Bargal R, Filocamo M, Raas-Rothschild A, Tappino B, Laprise C, Cury G, Schwartz I, Artigalás O, Prata M, Alves S. Origin and spread of a common deletion causing mucolipidosis type II: insights from patterns of haplotypic diversity. Clin Genet. 2011 Sep;80(3):273-80.
  81. Madore A-M, Laprise C. Immunological and genetic aspects of asthma and allergy. Journal of Asthma and Allergy. 2010; 3:107-121.
  82. Sasarman F, Brunel-Guitton C, Antonicka H, Wai T, Shoubridge EA; LSFC Consortium. LRPPRC and SLIRP interact in a ribonucleoprotein complex that regulates posttranscriptional gene expression in mitochondria. Mol Biol Cell. 2010 Apr 15;21(8):1315-23.
  83. Sirois-Gagnon D, Chamberland A, Perron S, Brisson D, Gaudet D, Laprise C. Association of Common Polymorphisms in the Fractalkine Receptor (CX3CR1) With Obesity. Obesity (Silver Spring). 2011 Jan;19(1):222-7.
  84. Madore AM, Perron S, Turmel V, Laviolette M, Bissonnette EY, Laprise C. Alveolar macrophages in allergic asthma: an expression signature characterized by heat shock protein pathways. Hum Immunol. 2010 Feb;71(2):144-50.
  85. Bossé Y, Lemire M, Poon AH, Daley D, He JQ, Sandford A, White JH, James AL, Musk AW, Palmer LJ, Raby BA, Weiss ST, Kozyrskyj AL, Becker A, Hudson TJ, Laprise C. Asthma and genes encoding components of the vitamin D pathway.Respir Res. 2009 Oct 24;10:98.
  86. Verlaan DJ, Berlivet S, Hunninghake GM, Madore AM, Larivière M, Moussette S, Grundberg E, Kwan T, Ouimet M, Ge B, Hoberman R, Swiatek M, Dias J, Lam KC, Koka V, Harmsen E, Soto-Quiros M, Avila L, Celedón JC, Weiss ST, Dewar K, Sinnett D, Laprise C, Raby BA, Pastinen T, Naumova AK. Allele-Specific Chromatin Remodeling in the ZPBP2/GSDMB/ORMDL3 Locus Associated with the Risk of Asthma and Autoimmune Disease. Am J Hum Genet. 2009 Sep;85(3):377-93.
  87. Boulet LP, Turcotte H, Prince P, Lemière C, Olivenstein R, Laprise C, Larivée P, Bégin P, Laviolette M. Benefits of low-dose inhaled fluticasone on airway response and inflammation in mild asthma. Respir Med. 2009 Oct;103(10):1554-63. Epub 2009 Aug 18.
  88. Zhang J, Daley D, Akhabir L, Stefanowicz D, Chan-Yeung M, Becker AB, Laprise C, Paré PD, Sandford AJ. Lack of association of TIM3 polymorphisms and allergic phenotypes. BMC Med Genet. 2009 Jun 30;10:62.
  89. He JQ, Hallstrand TS, Knight D, Chan-Yeung M, Sandford A, Tripp B, Zamar D, Bossé Y, Kozyrskyj AL, James A, Laprise C, Daley D. A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness. J Allergy Clin Immunol. 2009 Aug;124(2):222-9.
  90. Daley D, Lemire M, Akhabir L, Chan-Yeung M, He J, McDonald T, Sandford A, Stefanowicz D, Tripp B, Zamar D, Bossé Y, Ferretti V, Montpetit A, Tessier M-C, Becker A, Kozyrskyj AL, Beilby J, McCaskie PA, Musk B, Warrington N, James A, Laprise C, Palmer L, Paré PD, Hudson TJ. Analyses of associations with asthma in four asthma population samples from Canada and Australia. Human Genetics 2009 May;125(4):445-59.
  91. Chamberland A, Madore AM, Tremblay K, Laviolette M, Laprise C. A comparison of two microarray experiments to define asthma transcriptome. Exp Lung Res. 2009 Jun;35(5):399-410.
  92. Tewfik MA, Bossé Y, Lemire M, Hudson TJ, Vallée-Smejda S, Al-Shemari H, Laprise C, Desrosiers M. Polymorphisms in the toll-like receptor signaling pathway at the level of the interleukin-1 receptor-associated kinase-4 gene are associated with total serum IgE level. Allergy. 2009 May;64(5):746-53.
  93. Chamberland A, Tremblay N, Audet M, Gilbert B, Pérusse L, Vohl M-C, Laprise C. Association study between candidate genes and obesity-related phenotypes using a sample of lumberjacks. Public Health Genomics. 2009;12(4):253-8.
  94. Subbaro P, Becker A, Brook J.R, Daley D, Mandhane P.J, Miller G.E, Turvey S.E, Malcom R.S et al. On behalf of the CHILD study investigators. Expert Rev Clin Immunol. 2009; 5(1) : 77-95.
  95. Tremblay K, Daley D, Chamberland A, Lemire M, Montpetit A, Laviolette M, James A, Chang-Yeung M, Musk AW, Backer A, Sandford AJ, Paré PD, Hudson TJ, Laprise C. Genetic variation in immune signaling genes differentially expressed in asthmatic lung tissues. J Allergy Clin Immunol. 2008 Sep;122(3):529-36.
  96. Tremblay K, Potvin C, Lemire M, Salesse C, Tremblay A, Rabi B, Hudson TJ, Perez-Iratxeta C, Andrade-Navarro MA, Laprise C. Genes to diseases (G2D) computational method to identify asthma candidate genes. PLoS ONE. 2008 Aug 6;3(8):e2907.
  97. Madore A-M, Prévost C, Dorfman R, Durie P, Zielenski J, Laprise C. Distribution of CFTR mutations in Saguenay–Lac-Saint-Jean: proposal of a panel of mutations for population screening. Genet Med. 2008 Mar;10(3):201-6.
  98. Plante M, Lepage P, Brunet S, Roquis D, Claveau S, Hudson TJ, Morin C, Laprise C. Mucolipidosis type II : A unique causal mutation in the N-acetylglucosamine-1-phosphotransferase gene (GNPTAB) in a French Canadian Founder Population. Clin Genet. 2008 Mar;73(3):236-44.
  99. Madore A-M, Tremblay K, Hudson TJ, Laprise C. Replication of an association between 17q21 SNPs and asthma in a French-Canadian familial collection. Hum Genet. 2008 Feb;123(1):93-5.
  100. Madore A-M, Houde L, Vézina H,Vohl MC, Pérusse L, Mior N, Connelly PW, Laberge C, Hudson TJ, Gaudet D, Laprise C. Contribution of hierarchical clustering techniques to the modeling of the geographic distribution of genetic polymorphisms associated with chronic inflammatory diseases in the Quebec population. Community Genet. 2007;10(4):218-26.
  101. Boulet LP, Hamid Q; Bacon SL, Bergeron C, Boulet LP, Chen Y, Dixon AE, Ernst P, Hamid Q, Holguin F, Irvin CG, Kimoff RJ, Komakula S, Laprise C, Lavoie KL, Shore SA, Teodorescu M, Vohl MC. Symposium on obesity and asthma – November 2, 2006. Can Respir J. 2007 May-Jun;14(4):201-8. PMID: 17551594.
  102. Bégin P, Tremblay K, Daley D, Lemire M, Claveau S, Salesse C, Kacel S, Montpetit A, Becher A, Sandford AJ, Paré P, Hudson TJ, Laprise C. Association of Urokinase-type plasminogen activator with asthma. Am J Respir Crit Care Med. 2007 Jun 1;175(11):1109-16.
  103. Dufour D, Pichette A, Mshvildadze V, Bradette-Hébert M-E, Lavoie S, Longtin A, Laprise C, Legault J. Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Ledum groenlandicum Retzius. J Ethnopharmacol. 2006 Oct. 26.
  104. Bouhali T, Brisson D, Saint-Pierre J, Tremblay G, Perron P, Laprise C, Vohl MC, Vissers MN, Hutten BA, Després JP, Kastelein JJ, Gaudet D. Low plasma adiponectin concentration exacerbates the risk of premature coronary artery disease in familial hypercholesterolemia. Atherosclerosis 2008 Jan;196(1):262-9.
  105. Tremblay K, Provost V, Lemire M, Pastinen T, Renaud Y, Pagé N, Sandford A, Hudson TJ, Laviolette M and Laprise C. Association study between the CX3CR1 gene and asthma: a new candidate gene for asthma.Genes Immun. 2006 Dec;7(8):632-9.
  106. Boulet LP, Prince P, Turcotte H, Lemiere C, Olivenstein R, Laprise C, Larivee P, Begin P, Laviolette M. Clinical features and airway inflammation in mild asthma versus asymptomatic airway hyperresponsiveness. Respir Med 2006 ; 100 : 292-299.
  107. Poon AH, Laprise C,Lemire M, Hudson TJ, Schurr E. NRAMP1 is not associated with asthma, atopy, and serum immunoglobulin E levels in the French Canadian population. Genes Immun. 2005 Sep;6(6):519-27.
  108. Lemire M, Roslin NM, Laprise C, Hudson TJ, Morgan K. Transmission-ratio distortion and allele sharing in affected sib pairs: a new linkage statistic with reduced bias, with application to chromosome 6q25.3. Am J Hum Genet. 2004 Oct;75(4):571-86.
  109. Laprise C*, Poon A*, Lemire M, Montpetit A, Schurr E, Hudson TJ. Association of Vitamin D Receptor Genetic Variants with Susceptibility to Asthma and Atopy. Am J Respir Crit Care Med. 2004 Nov 1;170(9):967-73. *These authors contributed equally to this work.
  110. LaitinenT, PolviA, RydmanP, VendelinJ, MäkeläS, PulkkinenV, SalmikangasP, RehnM, PirskanenA, RautanenA, ZucchelliM, GullsténH, PetäysT, HaahtelaT, LaitinenA, Laprise C, HudsonTJ, LaitinenLA, Kere J. Characterization of a common susceptibility locus for asthma-related traits. Science 2004;304 (5668):300-4.
  111. Laprise C, Sladek R, Ponton A, Bernier M-C, Hudson TJ, Laviolette M. Functional classes of bronchial mucosa genes that are differentially expressed in asthma. BMC Genomics 2004; Mar 23;5(1):21.
  112. Raby BA, Klimecki W.T, Laprise C, Renaud Y, Faith J, Lemire M, Greenwood CM, Lange C, Palmer L, Lazarus R, Vercelli D, Kwiatkowski DJ, Silverman E, Martinez F, Hudson TJ, Weiss ST. Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes. Am J Human Genet 2002;166(11): 1449-56.
  113. Laitinen T, Daly MJ, Rioux J, Kauppi P, Laprise C, Petäys T, Green T, Cargill M, Haahtela T, Lander ES, Laitinen LA, Hudson TJ & Kere J. A susceptibility locus for asthma-related traits on chromosome 7 revealedby a genome-wide scan in a founder population. Nat Genet 2001 May;28(1):87-91.
  114. Gaudet D, Hudson TJ, Laberge C for the ECOGENE-21 (C Laprise is in charge of the SECTION III : Integration of genetic determinants of health in the population health assessment / surveillance and prevention / promotion process) and CARTAGENE teams. From Community Genetics to Community Genomics : The Quebec Experience. Community Genet 2000;3 :134-140.
  115. Laprise C, Boulet L-P, Morissette J, Winstall E, Raymond V. Evidence for linkage and association between atopy, airway hyperresponsiveness and the Glu237Gly of the ß subunit of the high-affinity receptor for immunoglobulin E (FcεRI-β). Immunogenetics 2000 Jul;51(8-9):695-702.
  116. Laprise C, Laviolette M, Boutet M, Boulet L-P. Asymptomatic airway hyperresponsiveness: relationships with airway inflammation and remodeling. Eur Respir J 1999 Jul; 14(1) : 63-73.
  117. Boulet LP, Chakir J, Dubé J, Laprise C, Boutet M, Laviolette M. Airway inflammation and structural changes in airway hyper-responsiveness and asthma: an overview. Can Respir J. 1998 Jan-Feb;5(1):16-21.
  118. Laprise C, Boulet L-P. Asymptomatic airway hyperresponsiveness: A three-year follow-up. Am J Respir Crit Care Med 1997; 156: 403-409.
  119. Boulet L-P, Turcotte H, Laprise C, Lavertu C, Bédard P-M, Lavoie A, Hébert J. Comparative degree and type of sensitization to common indoor and outdoor allergens in subjects with allergic rhinitis and/or asthma. Clin Exp Allergy 1997; 27: 52-59.
  120. Laprise C, Boulet L-P. Airway responsiveness and atopy in families of patients with asthma. Clin Invest Med 1996; 19(6): 461-469.
  121. Laprise C, Boulet L-P. Magnitude and determinants of short-term tachyphylaxis to methacholine in subjects with symptomatic or asymptomatic airway hyperresponsiveness and in normal controls. Respiration 1996;63(5):304-8.