Laprise C, Bouzigon E. Understand the allergic diseases biology using human populations by a transdisciplinary approach. Curr Opin Allergy Clin Immunol. 2014 Aug 1. Epub ahead of print.

Konya T, Koster B, Maughan H, Escobar M, Azad MB, Guttman DS, Sears MR, Becker AB, Brook JR, Takaro TK, Kozyrskyj AL, Scott JA; CHILD Study Investigators.Associations between bacterial communities of house dust and infant gut. Environ Res. 2014 May;131:25-30.

Laprise C. The Saguenay-Lac-St-Jean asthma familial collection : the genetics of asthma in a young founder population. Genes and Immunity. 2014 Mar 20  Apr;15(4):247-55.

Mühleisen T, Leber M, & al. Genome-wide association study reveals two new risk loci for bipolar disorder. Nature Communications. Nat Commun. 2014 Mar 11;5:3339.

Dizier MH, Margaritte-Jeannin P, Madore AM, Moffatt M, Brossard M, Lavielle N, Sarnowski C, Just J, Cookson W, Lathrop M, Laprise C, Bouzigon E, Demenais F. The nuclear factor I/A (NFIA) gene is associated with the asthma plus rhinitis phenotype. J Allergy Clin Immunol. 2014 Feb 20.

Bissonnette EY, Madore AM, Chakir J, Laviolette M, Boulet LP, Hamid Q, Bergeron C, Maghni K, Laprise C. Fibrolast growth factor-2 is s sputum rmeodeling biomarker of severe asthma. J Asthma. 2013 Nov 25.

Gauvin H, Moreau C, Lefebvre JF, Laprise C, Vézina H, Labuda D, Roy-Gagnon MH. Genome-wide patterns of identity-by-descent sharing in the French Canadian founder population. Eur J Hum Genet. 2013 Oct 16.

Laprise C, Bouzigon E. The genetics of asthma and allergic diseases: pieces of the puzzle are starting to come together. Curr Opin Allergy Clin Immunol. 2013 Oct;13(5):461-2.

Naumova AK, Al Tuwaijri A, Morin A, Vaillancout VT, Madore AM, Berlivet S, Kohan-Ghadr HR, Moussette S, Laprise C. Sex- and age-dependent DNA methylation at the 17q12-q21 locus associated with childhood asthma. Hum Genet. 2013 Jul;132(7):811-22.

Madore AM, Vaillancourt VT, Asai Y, Alizadehfar R, Ben-Shoshan M, Michel DL, Kozyrskyj AL, Becker A, Chang-Yeung M, Daley D, Clarke AE, Hull P, Sandford AJ and Laprise C. HLA-DQB1 is a genetic determinant for peanut allergy. Eur J Hum Genet. 2013 Feb 27.

Bchetnia M, Farez T, Duval J, Leclerc G, Dupérée A, Powell J, McCuaig C, Morin C, Legendre-Guillemin V, Laprise C. Microarray analysis of epidermolysis bullosa simplex-mottled pigmentation variant. J Dermatol Sci. 2013 Jan;69 (1):80-2.

Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL; CHILD Study Investigators. Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months. CMAJ. 2013 Mar 19;185(5):385-94.

T.Vaillancourt V, Bordeleau M, Laviolette M, Laprise C. From expression pattern to genetic association in asthma related phenotypes. BMC Res Notes. 2012 Nov 13;5:630.

Bouzigon E, Laprise C. Comprehensive integration of genetic and environmental determinants to increase knowledge of the allergic diseases. Curr Opin Allergy Clin Immunol. 2012 Oct;12(5):447-8.

Daley D, Park JE, He JQ, Yan J, Akhabir L, Stefanowicz D, Becker AB, Chan-Yeung M, Bossé Y, Kozyrskyj AL, James AL, Musk AW, Laprise C, Hegele RG, Paré PD, Sandford AJ. Associations and interactions of genetic polymorphisms in innate immunity genes with early viral infections and susceptibility to asthma and asthma-related phenotypes. J Allergy Clin Immunol. 2012 Dec;130(6):1284-93.

Boulay ME, Morin A, Laprise C, Boulet LP. Asthma and rhinitis: what is the relationship? Curr Opin Allergy Clin Immunol. 2012 Oct;12(5):449-54.

Morin A, Brook JR, Duchaine C, Laprise C. Association study of genes associated to asthma in a specific environment, in an asthma familial collection located in a rural area influenced by different industries.Int J Environ Res Public Health. 2012 Aug;9(8):2620-35.

Dizier MH, Margaritte-Jeannin P, Madore AM, Esparza-Gordillo J, Moffatt M, Corda E, Monier F, Guilloud-Bataille M, Franke A, Weidinger S, Annesi-Maesano I, Just J, Pin I, Kauffmann F, Cookson W, Lee YA, Laprise C, Lathrop M, Bouzigon E, Demenais F. The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma. J Allergy Clin Immunol. 2012 Jun;129(6):1547-53.

Poon AH, Gong L, Brasch-Andersen C, Litonjua AA, Raby BA, Hamid Q, Laprise C, Weiss ST, Altman RB, Klein TE. Very important pharmacogene summary for VDR. Pharmacogenet Genomics. 2012 May 14.

Verlaan DJ, Ouimet M, Adoue V, Sirois-Gagnon D, Larivière M, Ge B, Beaulieu P, Dias J, Lam KC, Koka V, Laprise C, Pastinen T, Sinnett D. Promoter polymorphisms in CHI3L1 are associated with asthma. J Allergy Clin Immunol. 2012 Aug;130(2):533-5.

Poon AH, Eidelman DH, Martin JG, Laprise C, Hamid Q. Pathogenesis of severe asthma. Clin Exp Allergy. 2012 May;42(5):625-37.

Poon A, Eidelman D, Laprise C, Hamid Q. ATG5, autophagy and lung function in asthma. Autophagy. 2012 Apr 1;8(4).

Lavoie JP, Lefebvre-Lavoie J, Leclere M, Lavoie-Lamoureux A, Chamberland A, Laprise C, Lussier J. Profiling of differentially expressed genes using suppression subtractive hybridization in an equine model of chronic asthma. PLoS One. 2012;7(1):e29440.

Poon AH, Chouiali F, Tse SM, Litonjua AA, Hussain SN, Baglole CJ, Eidelman DH, Olivenstein R, Martin JG, Weiss ST, Hamid Q, Laprise C. Genetic and histologic evidence for autophagy in asthma pathogenesis. J Allergy Clin Immunol. 2012 Feb;129(2):569-71.

Bchetnia M, Tremblay M-L, Leclerc G, Dupérée A, Powell J, McCuaig C, Morin C, Legendre-Guillemin V, Laprise C. Expression signature of epidermolysis bullosa simplex. Hum Genet. 2011 Aug 30.

Legault J, Perron T, Mshvildadze V, Girard-Lalancette K, Perron S, Laprise C, Sirois P, Pichette A. Antioxidant and Anti-Inflammatory Activities of Quercetin 7-O-β-D-Glucopyranoside from the Leaves of Brasenia schreberi. J Med Food. 2011 Aug 22.

Laprise C, Bouzigon E. To define the biological nature of asthma. Curr Opin Allergy Clin Immunol. 2011 Aug 11.

Poon A, Litonjua AA, Laprise C. Relevance and implication of genetic determinants to asthma pathophysiology. Curr Opin Allergy Clin Immunol. 2011 Aug 4.

Roy-Gagnon MH, Moreau C, Bherer C, St-Onge P, Sinnett D, Laprise C, Vézina H, Labuda D. Genomic and genealogical investigation of the French Canadian founder population structure. Hum Genet. 2011 Jan 15.

Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, von Mutius E, Farrall M, Lathrop M, Cookson WO; GABRIEL Consortium. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med. 2010;363(13):1211-21.

Coutinho M, Encarnação M, Gomes R, Da Silva Santos L, Martins S, Sirois-Gagnon D, Bargal R, Filocamo M, Raas-Rothschild A, Tappino B, Laprise C, Cury G, Schwartz I, Artigalás O, Prata M, Alves S. Origin and spread of a common deletion causing mucolipidosis type II: insights from patterns of haplotypic diversity. Clin Genet. 2011 Sep;80(3):273-80.

Madore A-M, Laprise C. Immunological and genetic aspects of asthma and allergy. Journal of Asthma and Allergy. 2010; 3:107-121.

 

Sirois-Gagnon D, Chamberland A, Perron S, Brisson D, Gaudet D, Laprise C. Association of Common Polymorphisms in the Fractalkine Receptor (CX3CR1) With Obesity. Obesity (Silver Spring). 2011 Jan;19(1):222-7.

Madore AM, Perron S, Turmel V, Laviolette M, Bissonnette EY, Laprise C. Alveolar macrophages in allergic asthma: an expression signature characterized by heat shock protein pathways. Hum Immunol. 2010 Feb;71(2):144-50.

Bossé Y, Lemire M, Poon AH, Daley D, He JQ, Sandford A, White JH, James AL, Musk AW, Palmer LJ, Raby BA, Weiss ST, Kozyrskyj AL, Becker A, Hudson TJ, Laprise C. Asthma and genes encoding components of the vitamin D pathway.Respir Res. 2009 Oct 24;10:98.

Verlaan DJ, Berlivet S, Hunninghake GM, Madore AM, Larivière M, Moussette S, Grundberg E, Kwan T, Ouimet M, Ge B, Hoberman R, Swiatek M, Dias J, Lam KC, Koka V, Harmsen E, Soto-Quiros M, Avila L, Celedón JC, Weiss ST, Dewar K, Sinnett D, Laprise C, Raby BA, Pastinen T, Naumova AK. Allele-Specific Chromatin Remodeling in the ZPBP2/GSDMB/ORMDL3 Locus Associated with the Risk of Asthma and Autoimmune Disease. Am J Hum Genet. 2009 Sep;85(3):377-93.

Boulet LP, Turcotte H, Prince P, Lemière C, Olivenstein R, Laprise C, Larivée P, Bégin P, Laviolette M. Benefits of low-dose inhaled fluticasone on airway response and inflammation in mild asthma. Respir Med. 2009 Oct;103(10):1554-63. Epub 2009 Aug 18.

Zhang J, Daley D, Akhabir L, Stefanowicz D, Chan-Yeung M, Becker AB, Laprise C, Paré PD, Sandford AJ. Lack of association of TIM3 polymorphisms and allergic phenotypes. BMC Med Genet. 2009 Jun 30;10:62.

He JQ, Hallstrand TS, Knight D, Chan-Yeung M, Sandford A, Tripp B, Zamar D, Bossé Y, Kozyrskyj AL, James A, Laprise C, Daley D. A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness. J Allergy Clin Immunol. 2009 Aug;124(2):222-9.

Daley D, Lemire M, Akhabir L, Chan-Yeung M, He J, McDonald T, Sandford A, Stefanowicz D, Tripp B, Zamar D, Bossé Y, Ferretti V, Montpetit A, Tessier M-C, Becker A, Kozyrskyj AL, Beilby J, McCaskie PA, Musk B, Warrington N, James A, Laprise C, Palmer L, Paré PD, Hudson TJ. Analyses of associations with asthma in four asthma population samples from Canada and Australia. Human Genetics 2009 May;125(4):445-59.

Chamberland A, Madore AM, Tremblay K, Laviolette M, Laprise C. A comparison of two microarray experiments to define asthma transcriptome. Exp Lung Res. 2009 Jun;35(5):399-410.

Tewfik MA, Bossé Y, Lemire M, Hudson TJ, Vallée-Smejda S, Al-Shemari H, Laprise C, Desrosiers M. Polymorphisms in the toll-like receptor signaling pathway at the level of the interleukin-1 receptor-associated kinase-4 gene are associated with total serum IgE level. Allergy. 2009 May;64(5):746-53.

Chamberland A, Tremblay N, Audet M, Gilbert B, Pérusse L, Vohl M-C, Laprise C. Association study between candidate genes and obesity-related phenotypes using a sample of lumberjacks. Public Health Genomics. 2009;12(4):253-8.

Subbaro P, Becker A, Brook J.R, Daley D, Mandhane P.J, Miller G.E, Turvey S.E, Malcom R.S et al. On behalf of the CHILD study investigators. Expert Rev Clin Immunol. 2009; 5(1) : 77-95.

Tremblay K, Daley D, Chamberland A, Lemire M, Montpetit A, Laviolette M, James A, Chang-Yeung M, Musk AW, Backer A, Sandford AJ, Paré PD, Hudson TJ, Laprise C. Genetic variation in immune signaling genes differentially expressed in asthmatic lung tissues. J Allergy Clin Immunol. 2008 Sep;122(3):529-36.

Tremblay K, Potvin C, Lemire M, Salesse C, Tremblay A, Rabi B, Hudson TJ, Perez-Iratxeta C, Andrade-Navarro MA, Laprise C. Genes to diseases (G2D) computational method to identify asthma candidate genes. PLoS ONE. 2008 Aug 6;3(8):e2907.

Madore A-M, Prévost C, Dorfman R, Durie P, Zielenski J, Laprise C. Distribution of CFTR mutations in Saguenay–Lac-Saint-Jean: proposal of a panel of mutations for population screening. Genet Med. 2008 Mar;10(3):201-6.

Plante M, Lepage P, Brunet S, Roquis D, Claveau S, Hudson TJ, Morin C, Laprise C. Mucolipidosis type II : A unique causal mutation in the N-acetylglucosamine-1-phosphotransferase gene (GNPTAB) in a French Canadian Founder Population. Clin Genet. 2008 Mar;73(3):236-44.

Madore A-M, Tremblay K, Hudson TJ, Laprise C. Replication of an association between 17q21 SNPs and asthma in a French-Canadian familial collection. Hum Genet. 2008 Feb;123(1):93-5.

Madore A-M, Houde L, Vézina H,Vohl MC, Pérusse L, Mior N, Connelly PW, Laberge C, Hudson TJ, Gaudet D, Laprise C. Contribution of hierarchical clustering techniques to the modeling of the geographic distribution of genetic polymorphisms associated with chronic inflammatory diseases in the Quebec population. Community Genet. 2007;10(4):218-26.

Boulet LP, Hamid Q; Bacon SL, Bergeron C, Boulet LP, Chen Y, Dixon AE, Ernst P, Hamid Q, Holguin F, Irvin CG, Kimoff RJ, Komakula S, Laprise C, Lavoie KL, Shore SA, Teodorescu M, Vohl MC. Symposium on obesity and asthma – November 2, 2006. Can Respir J. 2007 May-Jun;14(4):201-8. PMID: 17551594.

Bégin P, Tremblay K, Daley D, Lemire M, Claveau S, Salesse C, Kacel S, Montpetit A, Becher A, Sandford AJ, Paré P, Hudson TJ, Laprise C. Association of Urokinase-type plasminogen activator with asthma. Am J Respir Crit Care Med. 2007 Jun 1;175(11):1109-16.

Dufour D, Pichette A, Mshvildadze V, Bradette-Hébert M-E, Lavoie S, Longtin A, Laprise C, Legault J. Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Ledum groenlandicum Retzius. J Ethnopharmacol. 2006 Oct. 26.

Bouhali T, Brisson D, Saint-Pierre J, Tremblay G, Perron P, Laprise C, Vohl MC, Vissers MN, Hutten BA, Després JP, Kastelein JJ, Gaudet D. Low plasma adiponectin concentration exacerbates the risk of premature coronary artery disease in familial hypercholesterolemia. Atherosclerosis 2008 Jan;196(1):262-9.

Tremblay K, Provost V, Lemire M, Pastinen T, Renaud Y, Pagé N, Sandford A, Hudson TJ, Laviolette M and Laprise C. Association study between the CX3CR1 gene and asthma: a new candidate gene for asthma.Genes Immun. 2006 Dec;7(8):632-9.

Boulet LP, Prince P, Turcotte H, Lemiere C, Olivenstein R, Laprise C, Larivee P, Begin P, Laviolette M. Clinical features and airway inflammation in mild asthma versus asymptomatic airway hyperresponsiveness. Respir Med 2006 ; 100 : 292-299.

Poon AH, Laprise C,Lemire M, Hudson TJ, Schurr E. NRAMP1 is not associated with asthma, atopy, and serum immunoglobulin E levels in the French Canadian population. Genes Immun. 2005 Sep;6(6):519-27.

Lemire M, Roslin NM, Laprise C, Hudson TJ, Morgan K. Transmission-ratio distortion and allele sharing in affected sib pairs: a new linkage statistic with reduced bias, with application to chromosome 6q25.3. Am J Hum Genet. 2004 Oct;75(4):571-86.

Laprise C*, Poon A*, Lemire M, Montpetit A, Schurr E, Hudson TJ. Association of Vitamin D Receptor Genetic Variants with Susceptibility to Asthma and Atopy. Am J Respir Crit Care Med. 2004 Nov 1;170(9):967-73. *These authors contributed equally to this work.

LaitinenT, PolviA, RydmanP, VendelinJ, MäkeläS, PulkkinenV, SalmikangasP, RehnM, PirskanenA, RautanenA, ZucchelliM, GullsténH, PetäysT, HaahtelaT, LaitinenA, Laprise C, HudsonTJ, LaitinenLA, Kere J. Characterization of a common susceptibility locus for asthma-related traits. Science 2004;304 (5668):300-4.

Laprise C, Sladek R, Ponton A, Bernier M-C, Hudson TJ, Laviolette M. Functional classes of bronchial mucosa genes that are differentially expressed in asthma. BMC Genomics 2004; Mar 23;5(1):21.

Raby BA, Klimecki W.T, Laprise C, Renaud Y, Faith J, Lemire M, Greenwood CM, Lange C, Palmer L, Lazarus R, Vercelli D, Kwiatkowski DJ, Silverman E, Martinez F, Hudson TJ, Weiss ST. Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes. Am J Human Genet 2002;166(11): 1449-56.

Laitinen T, Daly MJ, Rioux J, Kauppi P, Laprise C, Petäys T, Green T, Cargill M, Haahtela T, Lander ES, Laitinen LA, Hudson TJ & Kere J. A susceptibility locus for asthma-related traits on chromosome 7 revealedby a genome-wide scan in a founder population. Nat Genet 2001 May;28(1):87-91.

Laprise C, Boulet L-P, Morissette J, Winstall E, Raymond V. Evidence for linkage and association between atopy, airway hyperresponsiveness and the Glu237Gly of the ß subunit of the high-affinity receptor for immunoglobulin E (FcεRI-β). Immunogenetics 2000 Jul;51(8-9):695-702.

Laprise C, Laviolette M, Boutet M, Boulet L-P. Asymptomatic airway hyperresponsiveness: relationships with airway inflammation and remodeling. Eur Respir J 1999 Jul; 14(1) : 63-73.

Boulet LP, Chakir J, Dubé J, Laprise C, Boutet M, Laviolette M. Airway inflammation and structural changes in airway hyper-responsiveness and asthma: an overview. Can Respir J. 1998 Jan-Feb;5(1):16-21.

Laprise C, Boulet L-P. Asymptomatic airway hyperresponsiveness: A three-year follow-up. Am J Respir Crit Care Med 1997; 156: 403-409.

Boulet L-P, Turcotte H, Laprise C, Lavertu C, Bédard P-M, Lavoie A, Hébert J. Comparative degree and type of sensitization to common indoor and outdoor allergens in subjects with allergic rhinitis and/or asthma. Clin Exp Allergy 1997; 27: 52-59.

Laprise C, Boulet L-P. Airway responsiveness and atopy in families of patients with asthma. Clin Invest Med 1996; 19(6): 461-469.

Laprise C, Boulet L-P. Magnitude and determinants of short-term tachyphylaxis to methacholine in subjects with symptomatic or asymptomatic airway hyperresponsiveness and in normal controls. Respiration 1996;63(5):304-8.